Tetracaine hydrochloride

Ibisobanuro birambuye

MF: C15H25ClN2O2
MW: 300.82
CAS: 136-47-0

1．Tetracaine hydrochloride ni anesthetic yaho ikora neza ishobora guhagarika imikorere yimitsi.Ikoreshwa muri anesthesia yinjira, anesthesia yumutima, anesthesia epidural, nibindi ugereranije na procaine, ingaruka za anesthesi yaho irahambaye, kandi yakoreshejwe cyane mumavuriro.Binyuze mu kwiga inzira zisanzwe zisanzwe, usanga ko synthesis ya p-butylamino acide hagati ya acide nintambwe yingenzi muguhuza hydrochloride ya tetracaine, ifite inenge yibikoresho fatizo bidahungabana cyangwa umusaruro muke.Abahanga bateje imbere ibi.Mu 1981, basabye guhuza aside p-butylamino benzoic acide p-aminobenzoic aside hamwe na 1-Bromobutane.Ariko, kubera gushiraho byanze bikunze ibicuruzwa biva muri dibutylation hamwe nimiterere idahwitse yibikoresho fatizo, iyi nzira ntabwo ibereye kubyara inganda.

2．Tetracaine hydrochloride ikoreshwa muburyo bwa anesthesia ya mucosal, anesthesia ya conduction, anesthesia epidural na anesthesia ya subarachnoid;Ikoreshwa kuri anesthesia yububabare bwamaso, ntabwo igabanya imiyoboro yamaraso, ntabwo yangiza epitelium ya corneal, kandi ntabwo yongera umuvuduko wimitsi.

3．Iyi miti irashobora kongera imbaraga zo guhagarika imitsi ya cisatracurium, kandi dosiye yanyuma igomba kugabanuka iyo ihujwe.Iyo ihujwe na adrenaline, irashobora kugabanya imiyoboro yamaraso, kugabanya umuvuduko wamaraso, gufata ibiyobyabwenge buhoro, no kongera igihe cyibikorwa.Ariko guhuza byombi ntibikwiye kubarwayi barwaye umutima, hypertension, hyperthyroidism, indwara yimitsi y'amaraso nibindi.Hyaluronidase irashobora kongera neza ikwirakwizwa ryibi biyobyabwenge, kwihutisha gutangira anesteziya, kugabanya kubyimba kwaho, no kwirinda indwara ya hematoma.Nyamara, hyaluronidase irashobora kandi kwihutisha iyinjizwa ryibi biyobyabwenge, bigatuma kwiyongera kwuburozi bwibitabo byibitabo byibiyobyabwenge byibi biyobyabwenge.Uyu muti ni inkomoko ya aside p-aminobenzoic (PABA).Sulfonamide igira antibacterial muguhagarika PABA ya bagiteri.Iyo uyu muti uhujwe na sulfonamide, ingaruka za antibacterial ya nyuma zizahagarikwa, bityo zombi ntizigomba guhuzwa.Uyu muti urimo aside kandi ntugomba kuvangwa nubuvuzi bwa alkaline;Ndetse imiti ya acide irashobora kugira ingaruka kubitandukanya nibiyobyabwenge bitewe na pH zitandukanye, bigatuma ibikorwa bigabanuka cyangwa gutinda gutangira.Gutegura iyode birashobora gutera imvura igwa, bityo aho gutera inshinge ntibishobora gukoreshwa.

Gusaba

Iki gicuruzwa nigihe kirekire-ester ikora anesthetic.Ibikorwa byayo biranga: kwinjira cyane muri mucosa, bikwiranye na anesthesia yo hejuru, kandi nta reaction mbi nka vasoconstriction, mydriasis, igikomere cya corneal nyuma yo gutonyanga amaso.Bikunze gukoreshwa mubuvuzi bw'amaso.Ingaruka za anesthetic zaho nuburozi bwikubye inshuro 10 kurenza procaine.Nyuma yo gutera inshinge, anesthetic yigitabo cyimiti igaragara buhoro (iminota 10), kandi metabolism nayo itinda nyuma yo kuyakira.Igihe cya anesthesi yaho igera kuri 3ij, h, -j.hafi.Ikoreshwa cyane cyane kuri anesthesia yo hejuru yijisho, izuru nu muhogo mucosa, kandi ni gake ikoreshwa mugutwara anesteziya na anesthesia epidural.Mubisanzwe, ntabwo ikoreshwa muri anesthesia yinjira kubera uburozi bwayo bwinshi.