Ubwiza Bwiza L-Glutathione Yagabanije CAS 70-18-8 yo Kwitaho Uruhu Glutathione

Ibisobanuro birambuye

MF: C10H17N3O6S
MW: 307.32
CAS: 70-18-8

1.Glutathione ni uruganda rwa tripeptide rwuzuyemo aside glutamic, cysteine ​​na glycine binyuze mumigozi ya peptide.Nibintu byingenzi cyane bya molekile ya mercaptan mungirangingo zinyamabere munsi ya antioxydeant.

2.Glutathione (GSH) ni uruganda rwa tripeptide rwakozwe na kanseri ya glutamic, cysteine ​​na glycine binyuze muri peptide.Izina ryimiti ni γ- Imiterere yuburyo bwa l-glutamyl-l-cysteyl-glycine irerekanwa mumashusho 1chemicalbook.Ukurikije formulaire yuburyo bugaragara, GSH itandukanye nizindi peptide na proteyine.Hariho peptide idasanzwe muri molekile yayo, ikozwe muri acide glutamic γ- Carboxyl (- COOH) na sisitemu α- Peptide umurunga uterwa no guhuza amine - (- NH2).

3.Uburemere bwa molekuline ya glutathione ni 307.33, aho gushonga ni 189 ~ 193 ℃ (decomposition), kristu nta ibara, rifite umucyo, inkingi yoroheje, naho ingingo ya isoelectric ni 5.93.Irashobora gushonga mumazi, ikanagura inzoga, ammonia yamazi na methyl formamide, ariko ntishobora gukomera muri alcool, ether na acetone.Gusa GSH ifite ibikorwa bya physiologique mubinyabuzima, kandi GSSG irashobora gukina imikorere yingenzi ya physiologique nyuma yo kugabanuka.GSH ntabwo yoroshye kubika munsi yibikorwa byamazi menshi, kandi irashobora kubikwa neza mugihe kirekire gusa mugihe ibikorwa byamazi bigenzuwe munsi ya 0.3.Ubushakashatsi bwerekanye ko mu gitabo cya vitamine ccchemicalbook amazi y’amazi arimo GSH (ph3.3), kubera kugabanuka gukabije kwa vitamine C, GSH mu gisubizo ntizaba oxyde kuri GSSG, ariko umuvuduko wacyo wihuta;GSSG muri vitamine C y'amazi yo mu mazi ntabwo izahindurwa muri GSH, kandi ububiko bwayo ni bwiza cyane.Byongeye kandi, GSSG yinjiye mu kanwa irashobora kugabanuka kuri GSH mugice cyo hejuru cy amara mato, hamwe nubuso bwingirabuzimafatizo ntoya yo mu nda γ- GTP (ibora GSH muri aside glutamic na Cys Gly) na dipeptidase nayo ishobora gukina physiologique yingenzi. imikorere.

4.Glutathione ibaho cyane mu nyamaswa n'ibimera, kandi ibiyirimo mu musemburo w'abatetsi, mikorobe y'ingano n'umwijima w'inyamaswa ni mwinshi cyane, kugeza 100 ~ 1000mg / 100g;Ikungahaye kandi ku maraso y’abantu n’inyamaswa, nkigitabo cya 26chemical ~ 34mg / 100g mumaraso yabantu, 58 ~ 73mg / 100g mumaraso yinkoko, 10 ~ 15mg / 100g mumaraso yingurube na 14 ~ 22mg / 100g mumaraso yimbwa.GSH iboneka no mu mboga nyinshi, ibirayi n'ibinyampeke.

Gusaba

1.Glutathione yagabanijwe ni peptide ntoya ya molekile, ibaho ku bwinshi mu binyabuzima, cyane cyane mu ngirangingo z'umwijima.Irashobora kurinda umwijima umwijima, igateza imbere ibikorwa byumusemburo wumwijima, kandi igahuza imiti myinshi yubumara mubitabo byimiti kugirango yanduze.Ifite ingaruka nziza ku gukomeretsa umwijima, cirrhose yumwijima nizindi ndwara ziterwa n'uburozi bwibiyobyabwenge, ubusinzi nizindi mpamvu.

2.Ifite imirimo ya antioxyde, gusiba radicals yubusa, kwangiza, kongera ubudahangarwa, gutinda gusaza, kurwanya kanseri, kwangiza imirase nibindi.

3.Biochemiki reagent na antidote bikoreshwa cyane cyane muburozi bwibyuma biremereye, acrylonitrile, fluoride, monoxide ya karubone hamwe nudukoko twangiza.

4.Endogenous antioxydants igira uruhare runini mukugabanya ubwoko bwa ogisijeni ikora mu gihe cyo guhinduranya ingirabuzimafatizo no guhumeka gitunguranye.Glutathione-S-transfert itera ishingwa rya glutathione sulfide hamwe na xenobiotics, leukotriène nizindi molekile hamwe na santere ya electrophilique.Glutathione kandi ikora disulfide ihuza ibisigazwa bya sisitemu muri poroteyine.Binyuze muri ubwo buryo, burashobora kugira ingaruka zidasanzwe zo kugabanya imikorere yimiti igabanya ubukana.